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Endotheliopathies and significant clotting pathologies are important clinical features of acute COVID-19 [338,339,340]

This method ensures maximum bioavailability, allowing the body to bypass the intrinsic factor requirement in the stomach that often limits the effectiveness of oral pills

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It enhances both synthesis and breakdown of extracellular matrix components, such as collagen, glycosaminoglycans (including dermatan and chondroitin sulfate), and decorin, and regulates metalloproteinases and their inhibitors (Pickart, Vasquez-Soltero, and Margolina 2015)